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What is “Microneedling”?
September 12, 2021

Skin – The Difficult Gap for Drugs to Cross

In the past, human beings usually took two methods to treat diseases, taking medicine or taking injections. However, taking medicine has the problem of low drug utilization rate and slow treatment, and injection will not only cause pain and damage normal human tissues, but also have the problems of possible cross-infection and environmental pollution by injection tools. Of course, there are times when a trainee nurse can be the lingering nightmare of your readers.

In order to improve this situation, since the 1970s, the transdermal drug delivery system with patches as the main treatment method has received attention as a new research direction. This mode of administration is beneficial to the long-term administration of the drug, and also greatly reduces the patient’s fear of the drug.

However, due to the existence of the stratum corneum of the skin, the permeability of the skin is poor. In a natural state, only drugs with a relative molecular mass less than 500 and good fat solubility can penetrate into the dermis and enter the systemic circulation through capillaries. However, the water-soluble drugs that dominate the clinical application and the biomacromolecules that have emerged in recent years are extremely difficult to absorb through the skin. Although physiologically, the skin is a barrier that prevents excessive loss of water from the body and prevents the entry of external pathogens and toxins. But in the case of dermal drug delivery, this barrier constitutes a major barrier to transdermal drug delivery to the dermis.

Do you know the origin of Fractional rf micro needle machine?

Taking medicine is slow, the injection is painful, and the ointment cannot penetrate deep into the skin. Is there a method that is as effective as the injection, but as painless as the ointment? This question also stumped many scientists.

One day in the hospital, a scientist saw a child crying loudly: “You lied to me! You said that an injection is as painless as a mosquito bite.” This sentence awakens the dreamer, and it is also a broken skin injection , Why is the injection so painful, but the mosquito bites have no feeling?

By analyzing existing experience and literature studies, scientists have identified three ways that mosquitoes avoid causing pain when sucking blood:

1. Numbness. They secrete saliva, which contains proteins that cause numbness.

2. Mouthparts with bunched zigzag design.

3. Vibration drive. When piercing the skin, the secretions or parts that draw blood vibrate, reducing the force required.

Inspired by the “painless blood-sucking” function of mosquitoes, scientists have developed a micro-nano-scale syringe needle, that is, a microneedle, imitating the structure of the mosquito mouth needle; the mosquito mouth needle is artificial in terms of piercing method, needle shape and needle tip structure The structural design and application of microneedles provide important inspiration.

What is Rf machine and want to know?

The microneedle needle body is a micron-scale structure, which is a hollow or solid structure, similar to our commonly used medical injection needles. The main drug that can be administered is the microneedle array on a substrate, that is, it is arranged and distributed in a certain array manner. on the substrate. The lengths of the microneedles vary, mainly because the thickness of the epidermis and dermis varies between human bodies, and different parts of the human body require microneedle arrays of different lengths. Microneedles can penetrate the stratum corneum of the skin and reach the epidermis of the human body, but at the same time, they do not touch the dermis where pain nerves are distributed, which can promote the penetration of drugs without making the human body feel pain or cause skin damage.

The structure of the microneedle is small, and it can be known from the epidermis and dermis structure of the skin that the damage of the microneedle to the skin will not be greater than that caused by people’s daily skin damage. In 1998, microneedles were first applied to the research in the field of transdermal drug delivery, which attracted the attention of many researchers in the field of transdermal drug delivery. Since then, many different types of microneedles have been developed by researchers.

Tips for using Secret gold micro needle:

Why can microneedling achieve painless treatment?

The reason why Golden needle can achieve painless drug delivery is determined by the structure of human skin and microneedle. Human skin can be divided into three layers from the surface to the inside: the stratum corneum, the active epidermis and the dermis.

Studies have shown that the stratum corneum formed by the accumulation of dead keratinocytes has a solid texture and forms a natural drug delivery barrier; the epidermis does not contain blood vessels, but has active cells and a small amount of nerve tissue; the innermost dermis is human skin. The main structure, the skin state of this layer determines the overall condition of the human skin. It contains a lot of nerve tissue, which can feel external stimuli, and also contains many active cells and vascular tissue. In order to ensure high drug penetration and no significant pain when microneedling penetrates the skin, the microneedling machine should penetrate the stratum corneum and epidermis, but not the nerve-rich dermis.

Therefore, in the design process of fractional rf microneedle machine, considering the overall structure of the skin, it is ensured that the height of the microneedle is greater than the thickness of the stratum corneum, so that the microneedle rf machine can break through the barrier of the stratum corneum to the delivery of active pharmaceutical ingredients to the deep layer of the skin, and at the same time, In order to realize pain relief of microneedle, its height should not exceed the sum of the thickness of stratum corneum and epidermis. However, in the actual application process of microneedles, the design height of microneedles is often greater than the sum of the thickness of the stratum corneum and epidermis. This is due to the elasticity of the skin, the uneven surface, and the combination of many factors such as the way of piercing and the structure of the needle body. Influence, when the radiofrequency microneedling penetrates the skin, the needle body cannot penetrate the skin completely; in addition, because the microneedle belongs to the micro-nano structure, even if the microneedle tip penetrates the dermis, it may not touch the nerve cells and blood vessels. Therefore, in practical applications, in order to ensure the use effect of the microneedles, the height of the microneedles is relatively high.

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